As cannabis legalization spreads across the United States, its use has become increasingly prevalent. While many perceive cannabis as harmless, recent research suggests significant cardiovascular risks associated with its consumption. A study published in JACC: Advances on March 18, 2025, reveals alarming associations between cannabis use and adverse cardiovascular events, particularly in individuals under 50 without prior cardiovascular conditions. People.com
The retrospective cohort study analyzed data from over 4.6 million adults aged 50 and younger, all free from significant cardiovascular comorbidities at baseline. Among these, 93,267 individuals (approximately 2%) were identified as cannabis users. The study's findings include:People.com
Myocardial Infarction (Heart Attack): Cannabis users exhibited a sixfold increase in heart attack risk compared to non-users.New York Post
Ischemic Stroke: The risk was four times higher among cannabis users.People.com
Heart Failure: Cannabis users faced a twofold increased risk.American College of Cardiology+1American College of Cardiology+1
Cardiovascular Death: There was a threefold increase in risk for cardiovascular-related mortality among cannabis users.American College of Cardiology+2AHA Journals+2AHA Journals+2
These statistics underscore cannabis as a novel and underrecognized risk factor for cardiovascular disease. People.com
The exact mechanisms by which cannabis influences cardiovascular health are still under investigation. However, several hypotheses have been proposed:
Sympathetic Nervous System Activation: Cannabis use can lead to increased heart rate and blood pressure, placing additional strain on the cardiovascular system.
Endothelial Dysfunction: Cannabis may impair the endothelium (the inner lining of blood vessels), affecting vascular tone and promoting atherosclerosis.
Proarrhythmic Effects: Some studies suggest that cannabis can alter heart rhythm, potentially leading to arrhythmias.
Understanding these mechanisms is crucial for developing targeted interventions and informing users about potential risks.
The study's focus on individuals under 50 is particularly concerning, as this demographic is often considered at lower risk for cardiovascular events. The findings challenge this notion, indicating that cannabis use can elevate cardiovascular risk even in younger populations without traditional risk factors. This emphasizes the need for heightened awareness and preventive measures among young adults who use cannabis.People.com
These findings align with previous research highlighting the cardiovascular risks of cannabis:
A study presented at the American College of Cardiology's Annual Scientific Session found that daily cannabis users were about one-third more likely to develop coronary artery disease compared to non-users. American College of Cardiology
Research published in the Journal of the American Heart Association linked cannabis use to a higher risk of stroke and heart failure.
These consistent findings across multiple studies reinforce the need for caution regarding cannabis use and cardiovascular health.American College of Cardiology+1AHA Journals+1
Given the emerging evidence, it is imperative for both patients and healthcare providers to engage in open discussions about cannabis use:
Patient Education: Individuals should be informed about the potential cardiovascular risks associated with cannabis.
Screening and Counseling: Healthcare providers should routinely inquire about cannabis use during medical evaluations and offer counseling on its potential health impacts.
Risk Assessment: Patients using cannabis should undergo regular cardiovascular risk assessments, especially if they have other risk factors such as hypertension or hyperlipidemia.
While cannabis may offer therapeutic benefits for certain conditions, its use is not without risks. The association between cannabis use and increased cardiovascular events, particularly among young adults, warrants attention and further research. As our understanding evolves, prioritizing cardiovascular health remains essential. Individuals should consult with healthcare professionals to make informed decisions about cannabis use in the context of their overall health.
American College of Cardiology (2025). Cannabis Use Substantially Increases Risk of Heart Attack.
https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/03/24/13/52/Cannabis-Use-Substantially-Increases-Risk-of-Heart-Attack-acc-2025
American College of Cardiology (2023). Frequent Marijuana Use Linked to Heart Disease.
https://www.acc.org/About-ACC/Press-Releases/2023/02/23/18/53/Frequent-Marijuana-Use-Linked-to-Heart-Disease
